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deepTMHMM Topology Viewer — NPC1 NPC1_chr18_23526442_23591506

Per-haplotype transmembrane topology predictions from JoGo haplotype-resolved proteome (deepTMHMM)

Gene Information ▼
Gene SymbolNPC1
Gene NameNPC intracellular cholesterol transporter 1
NCBI Gene IDGeneID:4864
EnsemblENSG00000141458.13
HGNCHGNC:7897
RefSeq ProteinNP_000262.2
Protein Length (ref)1278 aa
Haplotypes20
TM Helices (ref)13
Distinct Topologies4
Ref (a0001) Topologysignal(1-22)->TMhelix(270-291)->TMhelix(350-370)->TMhelix(621-639)->TMhelix(652-678)->TMhelix(686-706)->TMhelix(731-751)->TMhelix(759-783)->TMhelix(833-853)->TMhelix(1099-1117)->TMhelix(1122-1142)->TMhelix(1153-1173)->TMhelix(1194-1215)->TMhelix(1225-1251)
Genomic Regionchr18: 23526442-23591506
Topology Architecture Diagram ▼
Topology Differences vs Reference (a0001) ▼
Haplotype ▲▼ Diff Type ▲▼ Detail ▲▼
Haplotype Topology Details ▼
Summary Statistics ▼