| geneid | 29974 |
|---|---|
| ensemblid | ENSG00000148584.16 |
| hgncid | 24086 |
| symbol | A1CF |
| name | APOBEC1 complementation factor |
| refseq_nuc | NM_014576.4 |
| refseq_prot | NP_055391.2 |
| ensembl_nuc | ENST00000373997.8 |
| ensembl_prot | ENSP00000363109.3 |
| mane_status | MANE Select |
| chr | chr10 |
| start | 50799409 |
| end | 50885627 |
| strand | - |
| ver | v1.2 |
| region | chr10:50799409-50885627 |
| region5000 | chr10:50794409-50890627 |
| regionname0 | A1CF_chr10_50799409_50885627 |
| regionname5000 | A1CF_chr10_50794409_50890627 |
| chr:pos | ref | alt | af | annotation | impact | samples | AHAPIDS | ACHAPIDS | ACTHAPIDS | ACTGHAPIDS | ac | an | len | genename | geneid | featuretype | featureid | transcript_biotype | rank | hgvs_c | hgvs_p | cdna_pos_length | cds_pos_length | aa_pos_length | distance | status |
|---|
| genename | grch38/chm13v2 1/0: The haplotype type is the same as GRCh380/1: The haplotype type is the same as CHM13v20/0: The haplotype type matches neither GRCh38 nor CHM13v21/1: The haplotype type is the same on both GRCh38 and CHM13v2
|
ahapid | alen | total | AFR | AMR | EAS | EUR | SAS | aseq | chr | start | end |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1CF | 1/1 | a0001 | 586 | 325 | 77 | 49 | 145 | 12 | 40 | subcellular location copy fasta | chr10 | 50794409 | 50890627 |
Click to load Haplotype QTL data...
| pos | S. Strand |
E# Exon Number |
max | median | min | diff | type | haplotypeid | max_hap_list | min_hap_list | symbol | chr | start | end |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 50864033 | - | 2 | -0.2529 | -0.2409 | -0.2342 | 0.0186 | acceptor | a0001 | NA18947.hp2 NA18962.hp1 NA18986.hp1 |
HG02258.hp1 HG03139.hp1 HG06807.hp2 NA20300.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50864080 | - | 2 | 0.4265 | 0.3894 | 0.3641 | 0.0624 | donor | a0001 | HG01981.hp2 HG03139.hp2 |
HG02258.hp1 HG03139.hp1 HG06807.hp2 NA20300.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50859842 | - | 3 | -0.7703 | -0.7502 | -0.6956 | 0.0747 | acceptor | a0001 | NA18994.hp1 NA19002.hp1 NA19009.hp1 |
HG01981.hp2 HG03139.hp2 |
A1CF | chr10 | 50794409 | 50890627 |
| 50859985 | - | 3 | 0.8244 | 0.8118 | 0.7475 | 0.0769 | donor | a0001 | HG03669.hp2 | HG01884.hp2 HG01891.hp2 HG02055.hp1 HG02559.hp2 HG02572.hp1 others(4): Show |
A1CF | chr10 | 50794409 | 50890627 |
| 50843988 | - | 4 | -0.9977 | -0.9973 | -0.9972 | 0.0006 | acceptor | a0001 | HG02055.hp1 | HG02451.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50844122 | - | 4 | 0.9888 | 0.9886 | 0.9864 | 0.0025 | donor | a0001 | HG02683.hp1 | HG02258.hp1 HG02922.hp2 HG03139.hp1 HG06807.hp2 NA20300.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50841862 | - | 5 | -0.9968 | -0.9954 | -0.9952 | 0.0016 | acceptor | a0001 | HG02897.hp2 NA18906.hp1 |
NA18954.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50841992 | - | 5 | 0.9932 | 0.9927 | 0.9924 | 0.0008 | donor | a0001 | HG02897.hp2 | HG03540.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50836074 | - | 6 | -0.9723 | -0.9694 | -0.9578 | 0.0145 | acceptor | a0001 | HG02257.hp1 | HG02559.hp1 HG02717.hp1 HG03453.hp2 |
A1CF | chr10 | 50794409 | 50890627 |
| 50836312 | - | 6 | 0.9321 | 0.9282 | 0.9041 | 0.0280 | donor | a0001 | NA19002.hp2 | HG02559.hp1 HG02717.hp1 HG03453.hp2 |
A1CF | chr10 | 50794409 | 50890627 |
| 50828131 | - | 7 | -0.9962 | -0.9959 | -0.9956 | 0.0006 | acceptor | a0001 | HG02258.hp1 HG03139.hp1 HG06807.hp2 NA20300.hp1 |
HG01069.hp2 | A1CF | chr10 | 50794409 | 50890627 |
| 50828295 | - | 7 | 0.9756 | 0.9735 | 0.9717 | 0.0039 | donor | a0001 | NA19060.hp2 | HG02258.hp1 HG03139.hp1 HG06807.hp2 NA20300.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50820552 | - | 8 | -0.9959 | -0.9952 | -0.9947 | 0.0012 | acceptor | a0001 | HG02897.hp2 | HG01884.hp2 HG02055.hp1 HG02572.hp1 HG02630.hp1 NA19043.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50820649 | - | 8 | 0.9934 | 0.9932 | 0.9928 | 0.0007 | donor | a0001 | NA19011.hp2 | HG01884.hp2 HG02055.hp1 HG02572.hp1 HG02630.hp1 NA19043.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50816006 | - | 9 | -0.7555 | -0.7407 | -0.6862 | 0.0693 | acceptor | a0001 | NA18946.hp2 | HG03041.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50816279 | - | 9 | 0.8326 | 0.8216 | 0.7420 | 0.0906 | donor | a0001 | NA19076.hp1 | HG03942.hp2 | A1CF | chr10 | 50794409 | 50890627 |
| 50813857 | - | 10 | -0.7810 | -0.7582 | -0.7099 | 0.0712 | acceptor | a0001 | HG01884.hp2 | HG03225.hp2 | A1CF | chr10 | 50794409 | 50890627 |
| 50814038 | - | 10 | 0.6442 | 0.6093 | 0.5475 | 0.0967 | donor | a0001 | HG01884.hp2 | HG03225.hp2 | A1CF | chr10 | 50794409 | 50890627 |
| 50811040 | - | 11 | -0.9136 | -0.9050 | -0.8902 | 0.0234 | acceptor | a0001 | homoSapiens_grch38.hp1 | HG02735.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50811176 | - | 11 | 0.8153 | 0.8029 | 0.7911 | 0.0243 | donor | a0001 | HG01243.hp1 HG02723.hp2 |
HG02735.hp1 | A1CF | chr10 | 50794409 | 50890627 |
| 50809894 | - | 12 | -0.9888 | -0.9810 | -0.9767 | 0.0121 | acceptor | a0001 | HG02258.hp1 HG03139.hp1 HG06807.hp2 |
HG02895.hp1 HG02897.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50810042 | - | 12 | 0.9816 | 0.9803 | 0.9771 | 0.0045 | donor | a0001 | NA18945.hp1 NA18987.hp1 |
HG02895.hp1 HG02897.hp1 |
A1CF | chr10 | 50794409 | 50890627 |
| 50806880 | - | 13 | 0.9484 | 0.9096 | 0.8836 | 0.0648 | donor | a0001 | HG00280.hp2 HG00558.hp2 HG01346.hp1 HG01952.hp1 HG02027.hp2 others(10): Show |
HG01243.hp1 HG02723.hp2 |
A1CF | chr10 | 50794409 | 50890627 |
| pos | annotationhgvs_chgvs_p | clinvarid | clnsig | geneinfo | mc | clndisdb | strand strand
|
ahapid ahapid_count
|
chapid chapid count
|
thapid thapid_count
|
ghapid ghapid_count
|
AHAPIDS ahapids
|
ACHAPIDS achapids
|
ACTHAPIDS acthapids
|
ACTGHAPIDS actghapids
|
haplotypeids haplotypeids
|
impact | chr | ref | alt | external |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 50836093:splice 50836093:variant goto | c.585G>Ap.Ala195Ala | 786157 | Benign | A1CF:29974 | SO:0001819 synonymous_variant |
MedGen:C3661900 | - | 2 | 2 | 3 | 5 | a0001a0002 | a0001c0008a0002c0006 | a0001c0008t0001a0001c0008t0017a0002c0006t0006 | a0001c0008t0001g0039a0001c0008t0017g0042a0002c0006t0006g0044a0002c0006t0006g0045a0002c0006t0006g0046 | HG02451.hp2 HG02897.hp2 NA18906.hp1 NA18906.hp2 NA19240.hp2 |
LOW | chr10 | C | T | TogoVar |
| CHR:POS | annotationhgvs_chgvs_p | disease trait-log10podds or beta | AHAPIDS ahapids
|
ACHAPIDS achapids
|
ACTHAPIDS acthapids
|
ACTGHAPIDS actghapids
|
haplotypeids haplotypeids
|
study | initial sample size/replication sample size | report genes | mapped gene | strongest snp risk allele | strand strand
|
impact | chr | ref | alt |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
chr10:50886333
|
c.-846C>T | Urate levels0.057 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Genome-wide association analyses identify 18 new l others(47): Show |
49,825 European ancestry males, 60,522 European an others(57): Show |
A1CF, ASAH2 | A1CF - MIX23P2 | rs10821905-A | - | MODIFIER | chr10 | G | A |
|
chr10:50886333
|
c.-846C>T |
Estimated glomerular filtration rate0.00 others(2): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
A catalog of genetic loci associated with kidney f others(47): Show |
567,460 European ancestry individuals, 165,726 Eas others(211): Show |
A1CF | A1CF - MIX23P2 | rs10821905-A | - | MODIFIER | chr10 | G | A |
|
chr10:50885664
|
c.-177G>A |
Estimated glomerular filtration rate0.00 others(2): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
A catalog of genetic loci associated with kidney f others(47): Show |
567,460 European ancestry individuals/216,518 Euro others(25): Show |
A1CF | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50888694
|
c.-3207G>A | Estimated glomerular filtration rate in non-diabeticsothers(18): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Mapping eGFR loci to the renal transcriptome and p others(41): Show |
152,624 European ancestry individuals, 36,369 Afri others(25): Show |
A1CF | A1CF - MIX23P2 | rs10821907-T | - | MODIFIER | chr10 | C | T |
|
chr10:50885488
|
c.-94+93C>T |
Estimated glomerular filtration rate0.00 others(2): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Mapping eGFR loci to the renal transcriptome and p others(41): Show |
70,762 European ancestry diabetic individuals, 152 others(346): Show |
A1CF | A1CF | rs10994856-A | - | MODIFIER | chr10 | G | A |
|
chr10:50888694
|
c.-3207G>A |
Colorectal cancer or advanced adenoma1.0 others(1): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Discovery of common and rare genetic risk variants others(23): Show |
55,105 European ancestry cases, 3,026 East Asian a others(85): Show |
A1CF, PRKG1 | A1CF - MIX23P2 | rs10821907-C | - | MODIFIER | chr10 | C | T |
|
chr10:50808856
|
c.1609+1038A>G | Urate levels in lean individuals0.08 | a0001a0002a0003 | a0001c0001a0001c0002a0001c0003a0001c0005a0001c0007others(7): Show | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0009others(40): Show | a0001c0001t0001g0003a0001c0001t0001g0004a0001c0001t0001g0011a0001c0001t0001g0020a0001c0001t0001g0021others(239): Show | HG00140.hp1 HG00140.hp2 HG00280.hp1 HG00280.hp2 HG00423.hp1 others(282): Show |
Modulation of genetic associations with serum urat others(38): Show |
up to 5,529 European ancestry male individuals, up others(47): Show |
ASAH2B, A1CF | ASAH2B, A1CF | rs4256922-C | - | MODIFIER | chr10 | T | C |
|
chr10:50890011
|
c.-4524G>A | Narcolepsy with cataplexy1.8 | a0001a0002 | a0001c0001a0001c0002a0001c0003a0001c0009a0002c0004others(1): Show | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0005a0001c0001t0009others(12): Show | a0001c0001t0001g0134a0001c0001t0002g0126a0001c0001t0003g0033a0001c0001t0003g0061a0001c0001t0003g0128others(52): Show | HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01071.hp1 HG01123.hp2 others(63): Show |
A polymorphism in CCR1/CCR3 is associated with nar others(8): Show |
409 Japanese ancestry cases, 1,562 Japanese ancest others(71): Show |
A1CF | A1CF - MIX23P2 | rs4290173-C | - | MODIFIER | chr10 | C | T |
|
chr10:50885664
|
c.-177G>A | Glomerular filtration rate in non diabetics (creatinine)others(22): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Genetic associations at 53 loci highlight cell typ others(56): Show |
118,448 European ancestry individuals/36,433 Europ others(24): Show |
A1CF | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50888694
|
c.-3207G>A | Red blood cell count | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Leveraging Polygenic Functional Enrichment to Impr others(15): Show |
approximately 445,000 European ancestry individual others(2): Show |
A1CF - MIX23P2 | rs10821907-? | - | MODIFIER | chr10 | C | T | |
|
chr10:50885488
|
c.-94+93C>T | Urate levels0.052 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Genomic dissection of 43 serum urate-associated lo others(73): Show |
110,238 European ancestry individuals, 21,471 East others(19): Show |
A1CF | A1CF | rs10994856-G | - | MODIFIER | chr10 | G | A |
|
chr10:50885664
|
c.-177G>A | Urate levels0.064207 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Target genes, variants, tissues and transcriptiona others(48): Show |
288,649 European ancestry individuals/ | A1CF | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50885488
|
c.-94+93C>T | Serum uric acid levels0.03785714 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Genome-wide meta-analysis identifies multiple nove others(70): Show |
121,745 Japanese ancestry individuals, at least 88 others(35): Show |
A1CF | A1CF | rs10994856-A | - | MODIFIER | chr10 | G | A |
|
chr10:50882740
|
c.-94+2841G>A | Liver enzyme levels (gamma-glutamyl transferase)others(8): Show | a0001a0003 | a0001c0001a0001c0002a0001c0003a0003c0010 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0005a0001c0001t0007others(8): Show | a0001c0001t0001g0003a0001c0001t0001g0011a0001c0001t0001g0020a0001c0001t0001g0021a0001c0001t0001g0022others(58): Show | HG00140.hp2 HG00280.hp1 HG00544.hp2 HG00597.hp1 HG00621.hp1 others(68): Show |
Variance-quantitative trait loci enable systematic others(81): Show |
5,694 African ancestry individuals, 1,988 East Asi others(103): Show |
A1CF | rs10994838-? | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | Urate levels0.0733 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Target genes, variants, tissues and transcriptiona others(48): Show |
174,111 European, East Asian, African American, So others(125): Show |
NR | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50885664
|
c.-177G>A | Urate levels0.0523 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Target genes, variants, tissues and transcriptiona others(48): Show |
174,111 European, East Asian, African American, So others(125): Show |
NR | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50885664
|
c.-177G>A | Urate levels0.061 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Target genes, variants, tissues and transcriptiona others(48): Show |
288,649 European ancestry individuals, 125,725 Eas others(132): Show |
A1CF | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T |
|
chr10:50885488
|
c.-94+93C>T |
Estimated glomerular filtration rate6.45 others(1): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Sex-specific and pleiotropic effects underlying ki others(49): Show |
206,856 European ancestry individuals, 143,658 Eas others(29): Show |
A1CF, ASAH2B | A1CF | rs10994856-G | - | MODIFIER | chr10 | G | A |
|
chr10:50885664
|
c.-177G>A | Gout1.0941743 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
A genome-wide association analysis reveals new pat others(25): Show |
100,671 European ancestry cases, 2,106,212 Europea others(20): Show |
A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | Gout1.1104885 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
A genome-wide association analysis reveals new pat others(25): Show |
77,627 European ancestry cases, 933,894 European a others(17): Show |
A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | Serum urate levels0.0623 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
A genome-wide association analysis reveals new pat others(25): Show |
630,117 European ancestry individuals/ | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50885488
|
c.-94+93C>T |
Glomerular filtration rate (creatinine)0 others(5): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
1000 Genomes-based meta-analysis identifies 10 nov others(28): Show |
110,517 European ancestry individuals/ | A1CF | A1CF | rs10994856-A | - | MODIFIER | chr10 | G | A |
|
chr10:50883278
|
c.-94+2303A>G | Urate levels0.0421 | a0001 | a0001c0001 | a0001c0001t0005a0001c0001t0014 | a0001c0001t0005g0277a0001c0001t0005g0278a0001c0001t0005g0280a0001c0001t0005g0281a0001c0001t0005g0282others(1): Show | HG02280.hp1 HG03654.hp1 HG03831.hp2 HG03927.hp1 HG04184.hp2 others(1): Show |
Urate, Blood Pressure, and Cardiovascular Disease: others(76): Show |
454,183 European ancestry individuals/ | NR | A1CF | rs17592117-T | - | MODIFIER | chr10 | T | C |
|
chr10:50879173
|
c.-94+6408A>C | Cognitive function0.58 | a0001a0002a0003 | a0001c0001a0001c0002a0001c0003a0001c0005a0001c0009others(4): Show | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0005a0001c0001t0007others(34): Show | a0001c0001t0001g0003a0001c0001t0001g0004a0001c0001t0001g0020a0001c0001t0001g0021a0001c0001t0001g0022others(234): Show | HG00140.hp2 HG00280.hp1 HG00280.hp2 HG00423.hp2 HG00438.hp1 others(276): Show |
Genome-wide association study of population-standa others(75): Show |
2,211 Sub-Saharan African ancestry individuals/ | A1CF | rs6479768-G | - | MODIFIER | chr10 | T | G | |
|
chr10:50885488
|
c.-94+93C>T | Estimated glomerular filtration rate (creatinine)others(15): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Epigenomic and transcriptomic analyses define core others(64): Show |
1,205,871 European ancestry individuals, 168,300 E others(384): Show |
A1CF | rs10994856-A | - | MODIFIER | chr10 | G | A | |
|
chr10:50886333
|
c.-846C>T | Creatinine levels0.031592 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Characterising metabolomic signatures of lipid-mod others(61): Show |
110,051 European ancestry individuals/ | A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885488
|
c.-94+93C>T | Serum urate level in bendroflumethiazide treated hypertensionothers(27): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Genetic Determinants of Thiazide-Induced Hyperuric others(103): Show |
95,493 British ancestry individuals/ | A1CF | rs10994856-? | - | MODIFIER | chr10 | G | A | |
|
chr10:50886333
|
c.-846C>T | Estimated glomerular filtration rate (cystatin c)others(15): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Discovery and prioritization of variants and genes others(49): Show |
460,826 European or unknown ancestry individuals/ | A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50834010
|
c.604+2064A>G | Essential tremor0.8914553 | a0001 | a0001c0001a0001c0003a0001c0011 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0011a0001c0001t0035others(4): Show | a0001c0001t0001g0004a0001c0001t0001g0169a0001c0001t0001g0189a0001c0001t0001g0197a0001c0001t0001g0220others(59): Show | HG00438.hp2 HG00544.hp1 HG00558.hp1 HG00597.hp1 HG00621.hp2 others(73): Show |
Association of Essential Tremor With Novel Risk Lo others(54): Show |
7,177 European ancestry cases, 475,877 European an others(16): Show |
A1CF | rs16909866-C | - | MODIFIER | chr10 | T | C | |
|
chr10:50886333
|
c.-846C>T | Estimated glomerular filtration rate (creatinine)others(21): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Discovery and prioritization of variants and genes others(49): Show |
1,004,040 European ancestry individuals, 165,726 E others(189): Show |
A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885664
|
c.-177G>A | Estimated glomerular filtration rate (creatinine)others(15): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Discovery and prioritization of variants and genes others(49): Show |
1,004,040 European ancestry individuals/417,288 Eu others(27): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50852341
|
c.99+7501C>T | Serum urate levels0.0498 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0018a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260others(39): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01069.hp1 others(48): Show |
Large-scale cross-ancestry genome-wide meta-analys others(18): Show |
219,768 East Asian ancestry individuals/ | A1CF | rs10994720-A | - | MODIFIER | chr10 | G | A | |
|
chr10:50889433
|
c.-3946A>G | Colorectal cancer0.173862 | a0001a0002a0003 | a0001c0001a0001c0002a0001c0003a0001c0005a0001c0011others(2): Show | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0005a0001c0001t0007others(25): Show | a0001c0001t0001g0003a0001c0001t0001g0004a0001c0001t0001g0011a0001c0001t0001g0020a0001c0001t0001g0021others(184): Show | HG00140.hp1 HG00140.hp2 HG00280.hp1 HG00423.hp1 HG00423.hp2 others(221): Show |
New role of fat-free mass in cancer risk linked wi others(26): Show |
4,988 European ancestry cases, 310,272 European an others(16): Show |
A1CF - MIX23P2 | rs10761587-C | - | MODIFIER | chr10 | T | C | |
|
chr10:50878165
|
c.-94+7416T>C | Random glucose levels0.002197784 | a0001 | a0001c0001a0001c0002a0001c0003 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0012others(9): Show | a0001c0001t0001g0011a0001c0001t0001g0063a0001c0001t0001g0064a0001c0001t0001g0065a0001c0001t0001g0074others(41): Show | HG00140.hp1 HG00423.hp1 HG00423.hp2 HG00597.hp2 HG00735.hp1 others(53): Show |
GWAS of random glucose in 476,326 individuals prov others(87): Show |
7,644 African ancestry individuals, 1,503 Chinese others(106): Show |
A1CF | rs61856594-A | - | MODIFIER | chr10 | A | G | |
|
chr10:50878165
|
c.-94+7416T>C | Random glucose levels0.0022 | a0001 | a0001c0001a0001c0002a0001c0003 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0012others(9): Show | a0001c0001t0001g0011a0001c0001t0001g0063a0001c0001t0001g0064a0001c0001t0001g0065a0001c0001t0001g0074others(41): Show | HG00140.hp1 HG00423.hp1 HG00423.hp2 HG00597.hp2 HG00735.hp1 others(53): Show |
GWAS of random glucose in 476,326 individuals prov others(87): Show |
458,862 European ancestry individuals/ | A1CF | rs61856594-A | - | MODIFIER | chr10 | A | G | |
|
chr10:50885488
|
c.-94+93C>T | Serum urate levels0.0608 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Large-scale cross-ancestry genome-wide meta-analys others(18): Show |
219,768 East Asian ancestry individuals, 677,373 E others(50): Show |
A1CF | rs10994856-A | - | MODIFIER | chr10 | G | A | |
|
chr10:50885664
|
c.-177G>A | Serum urate levels0.0611 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Large-scale cross-ancestry genome-wide meta-analys others(18): Show |
677,373 European ancestry individuals/ | A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50883419
|
c.-94+2162G>A | Height0.0078 | a0001 | a0001c0001a0001c0002a0001c0003 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0012others(10): Show | a0001c0001t0001g0011a0001c0001t0001g0063a0001c0001t0001g0064a0001c0001t0001g0065a0001c0001t0001g0074others(43): Show | HG00140.hp1 HG00423.hp1 HG00423.hp2 HG00597.hp2 HG00735.hp1 others(55): Show |
A saturated map of common genetic variants associa others(22): Show |
5,314,291 European ancestry, Hispanic or Latin Ame others(79): Show |
A1CF | rs12244405-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A | Estimated glomerular filtration rate (cystatin c)others(18): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Variants in tubule epithelial regulatory elements others(60): Show |
406,504 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A | Estimated glomerular filtration rate (creatinine)others(17): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Variants in tubule epithelial regulatory elements others(60): Show |
406,504 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A | Estimated glomerular filtration rate (creatinine, cystatin c)others(28): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Variants in tubule epithelial regulatory elements others(60): Show |
406,504 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50882624
|
c.-94+2957T>C | Colorectal cancer0.0596 | a0001 | a0001c0001a0001c0002a0001c0003 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0012others(9): Show | a0001c0001t0001g0011a0001c0001t0001g0063a0001c0001t0001g0064a0001c0001t0001g0065a0001c0001t0001g0074others(41): Show | HG00140.hp1 HG00423.hp1 HG00423.hp2 HG00597.hp2 HG00735.hp1 others(53): Show |
Developing an optimal stratification model for col others(98): Show |
15,714 European ancestry cases, 621,182 European a others(88): Show |
A1CF | rs17500846-A | - | MODIFIER | chr10 | A | G | |
|
chr10:50886333
|
c.-846C>T | Gestational age (fetal effect)0.59030485 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Ultra-low-coverage genome-wide association study-i others(94): Show |
1,744 Chinese ancestry embryos/ | A1CF - MIX23P2 | rs10821905-? | - | MODIFIER | chr10 | G | A | |
|
chr10:50849248
|
c.100-5126A>G | Type 2 diabetes | a0001 | a0001c0001a0001c0003a0001c0011 | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0007a0001c0001t0011others(10): Show | a0001c0001t0001g0004a0001c0001t0001g0011a0001c0001t0001g0169a0001c0001t0001g0189a0001c0001t0001g0197others(77): Show | HG00140.hp1 HG00423.hp1 HG00438.hp2 HG00544.hp1 HG00558.hp1 others(98): Show |
Genetic drivers of heterogeneity in type 2 diabete others(18): Show |
50,251 African American cases, 103,909 African Ame others(353): Show |
A1CF | rs12570156-T | - | MODIFIER | chr10 | T | C | |
|
chr10:50886333
|
c.-846C>T | Colorectal cancer0.0634 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Deciphering colorectal cancer genetics through mul others(93): Show |
21,731 European ancestry cases, 47,444 European an others(88): Show |
A1CF - MIX23P2 | rs10821905-A | - | MODIFIER | chr10 | G | A | |
|
chr10:50888694
|
c.-3207G>A | Cystatin C levels in bottom 99% of individuals by creatinine levelsothers(37): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Genetic analysis of elevated levels of creatinine others(85): Show |
417,815 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-? | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A |
Estimated glomerular filtration rate based on creatinine and cystatin C in bottom 99% of individuals others(88): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Genetic analysis of elevated levels of creatinine others(85): Show |
417,815 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-? | - | MODIFIER | chr10 | C | T | |
|
chr10:50886333
|
c.-846C>T |
Gout and other crystal arthrop (PheCode 274)< others(11): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
44,197 European ancestry cases, 393,782 European a others(17): Show |
A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885664
|
c.-177G>A |
Gout and other crystal arthrop (PheCode 274)< others(10): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
14,867 African American or Afro-Caribbean cases, 1 others(272): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | Gout (PheCode 274.1)0.09033 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
14,437 African American or Afro-Caribbean cases, 1 others(272): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50886333
|
c.-846C>T | Gout (PheCode 274.1)0.1006 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
42,034 European ancestry cases, 397,989 European a others(17): Show |
A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885488
|
c.-94+93C>T | Takes medication for gout?0.1041 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
20,817 European ancestry cases, 294,851 European a others(17): Show |
A1CF | rs10994856-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885664
|
c.-177G>A | Gout (PheCode 274.1)0.1021 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
31,493 European ancestry cases, 284,175 European a others(17): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50883318
|
c.-94+2263T>C | Glucose levels0.0136 | a0001a0002a0003 | a0001c0001a0001c0002a0001c0003a0001c0005a0001c0007others(5): Show | a0001c0001t0001a0001c0001t0002a0001c0001t0003a0001c0001t0005a0001c0001t0007others(35): Show | a0001c0001t0001g0003a0001c0001t0001g0004a0001c0001t0001g0020a0001c0001t0001g0021a0001c0001t0001g0022others(217): Show | HG00140.hp2 HG00280.hp1 HG00280.hp2 HG00438.hp1 HG00438.hp2 others(256): Show |
A cross-population atlas of genetic associations f others(24): Show |
314,916 European ancestry individuals, 133,336 Eas others(29): Show |
A1CF | rs7075575-G | - | MODIFIER | chr10 | A | G | |
|
chr10:50885664
|
c.-177G>A | estimated glomerular filtration rate (eGFR, mean, inv-norm transformed)others(38): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
110,856 African American or Afro-Caribbean individ others(130): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
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chr10:50886333
|
c.-846C>T | creatinine (maximum, inv-norm transformed)others(9): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(5): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(35): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(43): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
116,285 African American or Afro-Caribbean individ others(130): Show |
A1CF - MIX23P2 | rs10821905-G | - | MODIFIER | chr10 | G | A | |
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chr10:50885664
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c.-177G>A | creatinine (minimum, inv-norm transformed)others(9): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
117,108 African American or Afro-Caribbean individ others(130): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
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chr10:50885664
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c.-177G>A |
creatinine (mean, inv-norm transformed)0 others(6): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
116,707 African American or Afro-Caribbean individ others(130): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
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c.-3207G>A | estimated glomerular filtration rate (eGFR, maximum, inv-norm transformed)others(41): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
110,850 African American or Afro-Caribbean individ others(130): Show |
A1CF - MIX23P2 | rs10821907-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | Serum uric acid levels0.0437 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
A cross-population atlas of genetic associations f others(24): Show |
343,836 European ancestry individuals, 129,405 Eas others(29): Show |
A1CF | rs10994860-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A | Serum creatinine levels0.0281 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
A cross-population atlas of genetic associations f others(24): Show |
344,104 European ancestry individuals, 150,266 Eas others(29): Show |
A1CF - MIX23P2 | rs10821907-T | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | creatinine (minimum, inv-norm transformed)others(9): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
421,910 European ancestry individuals/ | A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | estimated glomerular filtration rate (eGFR, mean, inv-norm transformed)others(38): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
398,886 European ancestry individuals/ | A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50888694
|
c.-3207G>A | estimated glomerular filtration rate (eGFR, maximum, inv-norm transformed)others(41): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0012others(6): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(37): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(45): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
398,886 European ancestry individuals/ | A1CF - MIX23P2 | rs10821907-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A | estimated glomerular filtration rate (eGFR, minimum, inv-norm transformed)others(41): Show | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
398,886 European ancestry individuals/ | A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885664
|
c.-177G>A |
creatinine (mean, inv-norm transformed)0 others(6): Show |
a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
421,411 European ancestry individuals/ | A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T | |
|
chr10:50885488
|
c.-94+93C>T | Takes medication for gout?0.1021 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
4,708 African American or Afro-Caribbean cases, 50 others(268): Show |
A1CF | rs10994856-G | - | MODIFIER | chr10 | G | A | |
|
chr10:50885664
|
c.-177G>A | Gout (PheCode 274.1)0.1 | a0001a0002 | a0001c0001a0001c0002a0002c0004 | a0001c0001t0001a0001c0001t0003a0001c0001t0005a0001c0001t0010a0001c0001t0014others(4): Show | a0001c0001t0001g0276a0001c0001t0003g0033a0001c0001t0003g0259a0001c0001t0003g0260a0001c0001t0003g0261others(29): Show | HG00438.hp1 HG00639.hp1 HG00735.hp2 HG00741.hp2 HG01081.hp2 others(37): Show |
Diversity and scale: Genetic architecture of 2068 others(41): Show |
6,538 African American or Afro-Caribbean cases, 48 others(268): Show |
A1CF | rs10994860-C | - | MODIFIER | chr10 | C | T |